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目的探讨洛伐他汀对慢性充血性心力衰竭(CHF)患者血清C-反应蛋白(CRP)水平变化的作用,了解他汀类药物对CHF患者心功能的影响。方法 34例慢性充血性心力衰竭(纽约心脏协会心功能分级标准心功能为Ⅲ～Ⅳ级)且血清C-反应蛋白增高患者,随机分成2组,A组14例,给予强心、利尿、ACEI和/或β受体阻滞剂治疗;治疗组20例在此基础上加用洛伐他汀20mg/d,待心功能改善Ⅰ～Ⅱ级后复抽取血清作C-反应蛋白测定及心脏左室射血分数检测。结果 A组治疗后患者血清C-反应蛋白增高阳性率43%;B组治疗后患者血清C-反应蛋白增高阳性率30%,(P<0.05);B组治疗前后患者心脏射血分数较A组治疗前后患者有改善(P<0.05)。结论炎症反应参与部分慢性充血性心力衰竭患者病情变化过程,他汀类药物能明显改善该过程,从而改善心功能。
Objective To investigate the effect of lovastatin on the level of serum C-reactive protein (CRP) in patients with chronic congestive heart failure (CHF) and to investigate the effect of statins on cardiac function in CHF patients. Methods Thirty-four patients with chronic congestive heart failure (New York Heart Association Cardiac Function Grading Standard Cardiac Function Grade Ⅲ ~ Ⅳ) and elevated serum C-reactive protein were randomly divided into two groups, Group A, 14 patients were given cardiac, diuretic, ACEI 20 patients in the treatment group were treated with lovastatin 20 mg / d on the basis of this study. Serum levels of C-reactive protein and cardiac left ventricular Ejection fraction test. Results The positive rate of serum C-reactive protein in group A after treatment was 43%. The positive rate of serum C-reactive protein in group B after treatment was 30% (P <0.05). Compared with group A, Patients before and after treatment improved (P <0.05). Conclusion Inflammatory reaction is involved in the course of disease in patients with chronic congestive heart failure. Statins can significantly improve the process and improve cardiac function.