淡黄蓟罂粟Argemone ochroleuca Sweet用于治疗咳嗽、支气管炎、哮喘等多种疾病,并具有多种药理活性。但该属植物对气管平滑肌药理作用的研究却鲜见报道。以豚鼠离体气管环为模型,并以生物活性为导向,分离、鉴定了活性成分小檗碱,评价了该植物的平喘作用,并对小檗碱的舒张气管? Argemone ochroleuca Sweet is used to treat various diseases such as cough, bronchitis, and asthma, and has a variety of pharmacological activities. However, studies on the pharmacological effects of tracheal smooth muscle in this genus are rarely reported. Using guinea pig isolated tracheal rings as a model, and guided by biological activity, the active ingredient berberine was isolated and identified, and the anti-asthmatic effect of the plant was evaluated, and the bronchodilating trachea of ​​berberine was evaluated.