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应用染色体技术和聚合酶链反应方法检测干扰素治疗慢性粒细胞白血病完全缓解后微量残留病28例的疗效。发现治疗后2例Ph’染色体阴转，长期应用干扰素组Ph’染色体阳性率下降，1例bcr／ab1mRNA转为阴性。而短期应用干扰素组无Ph’染色体变化，或bcr／ab1mRNA阴转。按目前我们应用干扰素的剂量、疗程，很难达到有效清除bcr／ab1mRNA阳性细胞的目的。
Chromosome technology and polymerase chain reaction method were used to detect the efficacy of interferon in the treatment of 28 patients with minimal residual disease after complete remission of chronic myeloid leukemia. Two Ph ’chromosome negative conversions were found after treatment. Ph’s chromosome positive rate was decreased in long-term interferon group and bcr/ab1 mRNA was negative in one case. In the short-term use of interferon group, there was no Ph’ chromosome change, or bcr/ab1 mRNA was negative. According to the current dose and course of application of interferon, it is difficult to achieve the purpose of effectively removing bcr/ab1 mRNA positive cells.