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目的探讨大肠腺瘤组织中脂及脂质过氧化与大肠腺瘤恶变的关系。方法病例来源于2007年1月—2009年12月在武汉大学人民医院进行结肠镜检查诊断为大肠腺瘤的120例患者,所有病例均在结肠镜下行高频电切除大肠腺瘤,取腺瘤组织匀浆后,检查组织中胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和丙二醛含量。结果远侧腺瘤组和绒毛状腺瘤组组织中胆固醇和丙二醛高于近侧腺瘤组和管状+混合状腺瘤组,差异有统计学意义(P<0.05);各组男女之间组织中胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和丙二醛含量比较,差异无统计意义(P>0.05)。结论大肠腺瘤组织中胆固醇含量和脂质过氧化增高是大肠腺瘤恶变的一个危险因素。
Objective To investigate the relationship between lipid and lipid peroxidation and malignant transformation of colorectal adenoma in colorectal adenoma. Methods From January 2007 to December 2009, 120 cases of colon adenoma were diagnosed by colonoscopy in Wuhan University People’s Hospital. All patients underwent colonoscopic resection of colorectal adenoma with high frequency, Tissue homogenates were examined for cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and malondialdehyde levels. Results Cholesterol and malondialdehyde were higher in distal adenoma group and villous adenoma group than in proximal adenoma group and tubular + mixed adenoma group (P <0.05) There were no significant differences in cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and malondialdehyde between the two groups (P> 0.05). Conclusion Cholesterol content and lipid peroxidation in colorectal adenomas are a risk factor for malignant transformation of colorectal adenomas.