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目的探讨低剂量肝酶诱导结合蓝光治疗新生儿黄疸的可行性。方法随机选取2013年1月至2014年5月新生儿黄疸患儿90例,按照治疗方式分为三组,蓝光组30例单用蓝光治疗,肝酶组30例单用肝酶诱导剂治疗,酶光组30例采用低剂量肝酶诱导结合蓝光治疗,比较三组疗效及不良反应。结果酶光组总有效率(96.67%)优于蓝光组(83.33%)和肝酶组(86.67%),差异有统计学意义(P<0.05)。不良反应率酶光组(13.33%)与蓝光组(9.99%)均低于肝酶组(30.00%),差异有统计学意义(P<0.05)。结论低剂量肝酶诱导结合常规蓝光治疗新生儿黄疸安全、可靠,是治疗新生儿黄疸的理想治疗方法,具有推广应用价值。
Objective To investigate the feasibility of low-dose liver enzyme induction combined with blue light treatment of neonatal jaundice. Methods Ninety neonates with jaundice were randomly selected from January 2013 to May 2014. The patients were divided into three groups according to the mode of treatment. Thirty patients in the blue group were treated with blue light alone, while the others in the liver group were treated with liver enzyme alone. Enzyme group 30 patients with low-dose liver enzyme induction combined with blue light therapy, efficacy and adverse reactions in the three groups were compared. Results The total effective rate of enzyme group (96.67%) was better than that of blue group (83.33%) and liver enzyme group (86.67%) (P <0.05). Adverse reaction rate was lower in the enzyme group (13.33%) and blue group (9.99%) than in the liver enzyme group (30.00%), the difference was statistically significant (P <0.05). Conclusion Low-dose liver enzyme induction combined with routine blue light treatment of neonatal jaundice is safe and reliable. It is an ideal treatment for neonatal jaundice and has the value of popularization and application.