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神经源性肺水肿(NPE)是癫痫持续状态SE常见的严重并发症,病死率高。本文报告诊治27例小儿SE并NPE的经验。 1 临床资料 1.1 一般资料本组27例中男性18例,女性9例,年龄8个月～13岁。临床诊断:既往有癲痫发作史的10例中,原发性癫痫6例,继发性癫痫4例,继发于新生儿窒息2例,颅内感染1例,脑外伤1例。其发作主要诱因有:停药4例,感染3例,不规则服药2例,原因不明1例;首发SE 17例病因:鼠药中毒10例(其中毒鼠强中毒6例,氟乙酰胺中毒4例),脑炎6例,脑肿瘤1例。SE类型:均以强直一阵挛发作为主。其中入院前持续抽搐时间在30min内者7例,2h以上者14例,6h以上者5例,12h以上者1例。入院时有肺水肿表现者16例,均为
Neurogenic pulmonary edema (NPE) is a common and serious complication of seizure status SE with high mortality. This article reports the diagnosis and treatment of 27 cases of pediatric SE and NPE experience. 1 Clinical data 1.1 General Information The group of 27 patients, 18 males and 9 females, aged 8 months to 13 years. Clinical diagnosis: history of seizures in the past 10 cases, the primary epilepsy in 6 cases, 4 cases of secondary epilepsy, secondary to neonatal asphyxia in 2 cases, 1 case of intracranial infection, 1 case of traumatic brain injury. The onset of the main incentives are: withdrawal in 4 cases, 3 cases of infection, irregular medication in 2 cases, 1 case of unknown cause; the first episode of 17 cases of etiology: rat poisoning in 10 cases (including tetramine poisoning in 6 cases, fluoroacetamide poisoning 4 cases), encephalitis in 6 cases, brain tumor in 1 case. SE type: all with a burst of tetanus as the main. Among them, there were 7 cases with persistent convulsions within 30 minutes before admission, 14 cases with more than 2 hours, 5 cases with more than 6 hours and 1 case with more than 12 hours. There were 16 cases of pulmonary edema on admission, both of them