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目的:研讨晚期癌症患者接受大剂量吗啡注射液镇痛对其重度疼痛症状的改善作用。方法:从本院肿瘤科2013年2月-2016年2月选取42例重度癌痛的晚期癌症患者参与研究试验,并按随机非盲法分组,Ⅰ组21例接受大剂量吗啡静脉推注,Ⅱ组21例接受大剂量吗啡注射液泵注,评估该两种方案的镇痛效果。结果:两组接受治疗前、后的NRS评测结果、每日癌痛发作次数相比均无显著差异,统计学不成立(P>0.05)。Ⅱ组吗啡每日最高使用量(176.8±32.2)mg,相比Ⅰ组的(391.8±82.4)mg显著减少,比较统计学成立(P<0.05)。结论:给予晚期癌症患者泵注大剂量吗啡注射液治疗,对缓解癌痛症状、减少吗啡用量均具有较好的效果,值得推荐。
OBJECTIVE: To study the effect of high-dose morphine injection on patients with advanced cancer in improving their severe pain symptoms. Methods: Forty-two patients with advanced cancer with severe cancer pain were enrolled in this study from February 2013 to February 2016 in our hospital. Randomized non-blinded patients were included in the study. Twenty-one patients in group Ⅰ received intravenous injection of high-dose morphine, Twenty-one patients in group Ⅱ received high-dose morphine injection to evaluate the analgesic efficacy of the two regimens. Results: There was no significant difference between the two groups in the NRS evaluation before and after treatment, the number of daily cancer pain episodes, and the statistics did not hold (P> 0.05). The daily maximum dosage of morphine in group Ⅱ was (176.8 ± 32.2) mg, which was significantly lower than that in group Ⅰ (391.8 ± 82.4 mg), and the statistical comparison was statistically significant (P <0.05). Conclusions: The treatment of patients with advanced cancer with high dose of morphine injection of parenteral injection of praziquantel has the good effect of relieving the pain and relieving pain and reducing the dosage of morphine, which is worth recommending.