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目的探讨和研究前列腺摘除术与去势术对血清中雄激素(T、FT、DHT)的变化。方法39例研究对象,其中23例前列腺摘除术,16例去势术在手术前后分别采集血清样本,用放射免疫法测定血清中T、FT、DHT浓度。结果 前列腺摘除术后血清中T、FT、DHT分别较术前下降34.45％,33.53％,50.41％;去势术后血清中T、FT、DHT分别较术前下降92.27％,92.26％,58.36％。两种手术前后血清中T、FT、DHT的变化都有显著的统计学意义(P<0.001)。结论 前列腺摘除术后血清中雄激素会发生明显的变化,以DHT改变为显著。而去势术能够去除绝大部分T、FT,而DHT仅下降58.36%,在雄激素依赖的前列腺癌病例应当继续使用雄激素受体竞争剂,阻止残存的雄激素作用。
Objective To study and study the changes of serum androgen (T, FT, DHT) in prostatectomy and castration surgery. Methods Thirty-nine subjects were enrolled. Twenty three patients underwent prostatectomy and 16 underwent ovariectomy. Serum samples were collected before and after surgery. Serum concentrations of T, FT and DHT were measured by radioimmunoassay. Results The serum levels of T, FT and DHT decreased 34.45%, 33.53% and 50.41% respectively after the prostatectomy. The levels of T, FT and DHT decreased 92.27%, 92.26% and 58.36% . The changes of serum T, FT and DHT before and after the two operations were statistically significant (P <0.001). Conclusions There is a significant change of serum androgen after prostatic extirpation, which is marked by the change of DHT. Ovariectomy removed most of the T, FT, whereas DHT decreased only 58.36%. Androgen receptor competitors should continue to be used in androgen-dependent prostate cancer to prevent residual androgenic effects.