肝纤维化的发病机制较为复杂,目前Wnt信号转导通路与肝纤维化的研究引起了广大学者的关注。通过文献查阅综述了Wnt信号在肝纤维化过程中的作用及该通路干预抗肝纤维化,为此指出了关于该通路研究空白,这可能将为揭示肝纤维化的发病机制及其干预治疗提供可能的研究方向,并可能为临床治疗诊断肝纤维化提供理论基础。 The pathogenesis of liver fibrosis is more complicated. At present, the research of Wnt signaling pathway and hepatic fibrosis has aroused the attention of many scholars. The role of Wnt signaling in hepatic fibrosis and the intervention of this pathway on hepatic fibrosis were reviewed through literature review. Therefore, the gap in this pathway was pointed out, which may provide some evidences to reveal the pathogenesis of hepatic fibrosis and its interventional therapy Possible research directions, and may provide a theoretical basis for the clinical diagnosis of liver fibrosis.