乙型肝炎病毒 (HBV)在慢性感染过程中具有适应性和变异性的倾向 ,在内源性 (宿主免疫清除 )和外源性 (疫苗、抗病毒药物 )选择压力下更易产生免疫逃逸的变异株[1 ] 。HBV变异常出现某些特定位点 ,如前核心区 (前C区nt1896)及启动子(BCP ,nt1762 1764 )变异。在HBeAg阳性患者极 The tendency of hepatitis B virus (HBV) to have adaptability and variability during chronic infection is more likely to result in immune escape variability under the choice of endogenous (host immune clearance) and exogenous (vaccine, antiviral) selection pressure Strain [1]. Some specific sites of HBV mutation often appear, such as the mutation of the former core region (nt1896) and promoter (BCP, nt1762 1764). Very positive in HBeAg-positive patients