论文部分内容阅读
金葡球菌、大肠埃希氏菌和铜绿假单胞菌各２株分别感染小鼠，甲磺酸左氟沙星口服给药，以评价其体内保护作用。甲磺酸左氟沙星对２株金葡球菌感染小鼠的ＥＤ５０分别为５．２３和７．０４ｍｇ／ｋｇ，对２株大肠埃希氏菌感染小鼠的ＥＤ５０分别为０．４２和０．９５ｍｇ／ｋｇ，对２株铜绿假单胞菌感染小鼠的ＥＤ５０分别为１７．８和２２．４ｍｇ／ｋｇ。甲磺酸左氟沙星对小鼠全身感染的保护作用与对照药左氟沙星游离碱相似，而优于或相当于氧氟沙星和环丙沙星。
Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were each infected with two mice, oral administration of levofloxacin mesylate in order to evaluate its in vivo protective effect. The ED50 of levofloxacin mesylate in two S.aureus-infected mice were 5.23 and 7.04 mg / kg, respectively. The ED50 of two strains of E.coli-infected mice were 0.42 and 0 .95mg / kg, ED50 of the two strains infected with Pseudomonas aeruginosa were 17.8 and 22.4mg / kg, respectively. The protective effect of levofloxacin mesylate on mice with systemic infection was similar to that of the control drug levofloxacin free base, but superior to or equivalent to ofloxacin and ciprofloxacin.