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目的探讨低分子右旋糖酐治疗儿童肾病综合征致重度水肿的疗效。方法收集2008年1月-2010年6月本院收治的符合儿童肾病综合征致重度水肿诊断标准的患儿96例,并将其分为低分子右旋糖酐组(50例)和清蛋白组(46例)。观察2组治疗前、后尿量,水肿消退时间,治疗前、后血浆清蛋白变化情况并进行比较。结果低分子右旋糖酐组和清蛋白蛋组治疗前、后尿量[(358±135)mL.L-1vs(360±140)mL.L-1;(1 280±465)mL.L-1vs(1 285±510)mL.L-1],水肿消退时间[(6.1±2.0)dvs(5.9±1.8)d],治疗前、后血浆清蛋白水平[(11.6±4.2)g.L-1vs(12.0±3.8)g.L-1、(12.6±3.9)g.L-1vs(13.9±3.0)g.L-1]比较差异均无统计学意义(Pa>0.05)。结论应用低分子右旋糖酐治疗儿童肾病综合征致重度水肿的效果良好,值得临床推广。
Objective To investigate the therapeutic effect of low molecular weight dextran on severe edema in children with nephrotic syndrome. Methods Ninety-six children with nephrotic syndrome who were diagnosed as severe edema in our hospital from January 2008 to June 2010 were collected and divided into low molecular dextran group (50 cases) and albumin group (46 cases) example). The changes of plasma albumin before and after treatment, the extinction time of edema, the albumin before and after treatment were observed and compared in two groups. Results Before and after treatment, the urine volume of low molecular dextran group and albumin group were (358 ± 135) mL.L-1 vs (360 ± 140) mL.L-1; (1280 ± 465) mL.L-1vs (11 ± 4.2) gL-1vs (12.0 ± 1), serum creatinine level before and after treatment (P <0.05) 3.8) gL-1, (12.6 ± 3.9) gL-1vs (13.9 ± 3.0) gL-1]. There was no significant difference between the two groups (Pa> 0.05). Conclusion The application of low molecular weight dextran in children with nephrotic syndrome caused by severe edema effect is good, worthy of clinical promotion.