目的:探究高压氧联合温针灸治疗对强直性脊柱炎(AS)患者躯体功能、关节活动度改善及对炎性因子水平的影响。方法:选取2017年6月至2018年12月烟台市烟台山医院收治的128例AS患者作为研究对象，采用随机数字表法将患者分为对照组(n n＝64)和观察组(n n＝64)。2组患者均给予常规治疗，在常规治疗的基础上，对照组给予温针灸治疗，观察组给予温针灸联合高压氧治疗。采用Bath AS功能指数量表(BASFI)评估患者躯体功能及关节活动度，同时结合视觉模拟量表(VAS)评分评价腰骶脊背疼痛及关节疼痛情况；采用酶联免疫吸附法(ELISA)检测炎性因子水平的变化。n 结果:2组患者治疗后躯体功能及疼痛情况较治疗前有明显改善，且观察组患者BASFI和VAS评分均显著低于对照组，差异均有统计学意义(n P<0.05)。2组患者胸廓活动度、Schober试验、指地距、腰椎侧屈、腰椎后仰度及枕墙距较治疗前明显好转，且观察组患者改善情况优于对照组，差异均有统计学意义(n P<0.05)。炎性因子红细胞沉降率(ESR)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平也明显降低，且观察组显著低于对照组，差异均有统计学意义(n P<0.05)。观察组治疗总有效率(92.19%)显著高于对照组(78.13%)，差异有统计学意义(n P<0.05)。n 结论:高压氧联合温针灸治疗能提高AS的疗效，有效降低患者炎性因子水平，减轻患者疼痛，改善躯体功能及关节活动能力。“,”Objective:To explore the effects of hyperbaric oxygen (HBO) combined with warming needle moxibustion on the improvement of physical function, joint range of motion, and inflammatory factors in patients with ankylosing spondylitis (AS).Methods:A total of 128 AS patients admitted to the Department of Traditional Chinese Medicine of Yantai Mountain Hospital from June 2017 to December 2018 were selected as the study objects and randomly divided into control group (n n=64) and observation group (n n=64). The control group was given conventional treatment combined with warming needle moxibustion, and the observation group was given HBO on the basis of the treatments in the control group. The physical function of the patients was assessed by using the Bath Ankylosing Spondylitis Functional Index (BASFI), and the visual analogue scale (VAS) score was included to jointly evaluate the lumbosacral back pain and joint pain. The Bath Ankylosing Spondylitis Metrology Index (BASMI) was used to assess joint range of motion, and the enzyme linked immunosorbent assay (ELISA) was used to detect the changes in inflammatory factor levels before and after treatment.n Results:After treatment, the physical function and the severity of pain of the patients in both groups were significantly improved compared with those before treatment (n P<0.05), and the BASFI and VAS scores of the observation group were significantly lower than those of the control group (n P<0.05). Meanwhile, the test results of thoracic range of motion, Schober test, fingertips to floor distance, lumbar lateral flexion, extension of the lumbar spine, and occiput to wall distance were all significantly improved, and the improvements of the above tests in the observation group wee all greater than those in the control group, all with statistically significant differences (n P<0.05). The levels of inflammatory factors, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) significantly decreased (n P<0.05), moreover, the levels of those factors in the observation group were all lower than those in the control group, all with statistically significant differences (n P<0.05). The total effective rate in the observation group (92.19%) was higher than that in the control group (78.13%), and the difference was statistically significant (n P<0.05).n Conclusion:Hyperbaric oxygen combined with warming needle moxibustion can significantly improve the curative effect on AS patients by effectively reducing the levels of inflammatory factors, decreasing the pain, and improving the physical function and joint range of motion, which is worthy of clinical promotion and application.