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钠是高血压形成中的一个重要因素,流行病学研究表明,未开化民族中不接触盐的人群不发生高血压病,而在饮食中摄盐的社会中高血压病的发生很普遍,临床上用利盐药及低盐饮食减少体内钠均可降低血压,实验显示盐敏感株大鼠在盐负荷下可诱发高血压。由于方法上的问题,大多系测定细胞外液、血浆容量及细胞外钠浓度。晚近,发展了测定白细胞内钠及其他阳离子的方法,白细胞代表活的有核细胞,Edmonson发现高血压病人白细胞内的钠和水含量增加。本文报道高血压病人在用四种降压药物治疗前后白细胞内水和阳离子的变化。
Sodium is an important factor in the formation of high blood pressure. Epidemiological studies have shown that hypertension is not found in people who are not exposed to salt in the uncivilized nation. Hypertension is common in those who take salt in the diet. Clinically With salt medicine and low-salt diet to reduce the body’s sodium can reduce blood pressure, the experiment showed that salt-sensitive strain rats can induce hypertension under salt load. Due to the methodological problems, most of the extracellular fluid, plasma volume and extracellular sodium concentration were determined. More recently, methods for measuring sodium and other cations in leukocytes have been developed. Leukocytes represent living nucleated cells and Edmonson found that white blood cells have increased sodium and water levels in hypertensive patients. This article reports the changes in leukocyte water and cations in hypertensive patients before and after treatment with four antihypertensive drugs.