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目的分析三氧化二砷(As2O3)治疗全反式维甲酸(ATRA)诱导缓解后复发的急性早幼粒细胞白血病(APL)患者的疗效和不良反应。方法0.1%As2O3注射液10ml加入5%葡萄糖注射液500ml稀释,持续3～4h静脉滴注,1次/d,儿童根据年龄酌减。结果11例ATRA诱导缓解后复发的APL患者,10例达完全缓解(CR),CR率90.9%,未发生明显不良反应。结论0.1%As2O3注射液治疗ATRA诱导缓解后复发的APL是有效且安全的。
Objective To evaluate the efficacy and adverse reactions of arsenic trioxide (As2O3) in the treatment of patients with acute promyelocytic leukemia (APL) relapsed after all-trans retinoic acid (ATRA) induction. Methods 0.1ml As2O3 injection 10ml 5% glucose injection 500ml diluted for 3 ~ 4h intravenous infusion, 1 / d, children reduce according to age. Results Eleven patients with APL relapsed after induction of remission had complete remission (CR) in 10 patients and a CR rate of 90.9%. No obvious adverse reactions occurred. Conclusion 0.1% As2O3 injection in the treatment of ATRA-induced APL relapse after remission is effective and safe.