应用极谱氧传感检测仪，测定红细胞中的ＳＯＤ活性来鉴定Ｄｏｗｎ＇ｓ，探索替代传统的染色体诊断方法。本文检测６２例健康人红细胞的ＳＯＤ为６９３５±４８７ｕ／ｍｌ，３２例Ｄｏｗｎ＇ｓ红细胞的ＳＯＤ为１０６０２±８２９ｕ／ｍｌ。而检测４８例健康新生儿红细胞的ＳＯＤ为５６２７±４６３ｕ／ｍｌ，３６例健康胎儿红细胞的ＳＯＤ为５７０７±４７５ｕ／ｍｌ，５例Ｄｏｗｎ＇ｓ新生儿红细胞的ＳＯＤ为８３０７±２２９ｕ／ｍｌ。研究结果显示Ｄｏｗｎ＇ｓ比健康人的红细胞ＳＯＤ高１．５倍，两者具有显著性差异。本方法检测快速，只需５０分钟，灵敏度高，操作简便，具有实用推广价值。 Polarographic oxygen sensor detector, determination of SOD activity in erythrocytes to identify Down’s, to explore alternative methods of traditional chromosomal diagnosis. In this paper, 62 cases of healthy human erythrocyte SOD was 6935 ± 487u / ml, 32 cases of Down’s red blood cell SOD was 10602 ± 829u / ml. The SOD of 48 healthy healthy newborn erythrocytes was 5627 ± 463u / ml, the SOD of 36 healthy fetuses was 5707 ± 475u / ml, and that of 5 Down’s newborn erythrocytes was 8307 ± 229u / ml. The results showed that Down’s is 1.5 times higher than healthy people’s erythrocyte SOD, both of which have significant differences. The method of rapid detection, just 50 minutes, high sensitivity, easy to operate, with practical promotion value.