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剖析生长因子与其受体结合后启动DNA合成前发生的一系列过程是细胞生物学和分子生物学的主要任务。将生长因子信号转导给细胞的机器、包括生长因子受体、生长因子受体的底物、一些关键酶(包括激酶和脂酶)、细胞骨架蛋白、转录作用因子、DNA结合蛋白以及与DNA复制有关的酶等。推测生长因子诱导DNA合成、恶性转化可能经过以下过程。 1、生长因子与细胞表面的相应受体结合使受体结构改变,在细胞膜表面重新分配,或
A series of processes that take place before DNA synthesis is initiated after the binding of growth factors to their receptors is the main task of cell biology and molecular biology. Machines that transduce growth factor signals to cells, including growth factor receptors, growth factor receptor substrates, key enzymes (including kinases and lipases), cytoskeletal proteins, transcription factors, DNA binding proteins, and DNA Copy related enzymes etc. It is speculated that growth factor-induced DNA synthesis and malignant transformation may go through the following process. 1. The binding of growth factors to the corresponding receptors on the cell surface changes the structure of the receptor, redistributing it on the surface of the cell membrane, or