丛艳彬~1,迟相林~(1,2)(1.青岛大学医学院威海市中心医院神经内科,山东威海264423;2.山东大学医学院)通常所说的老年性痴呆主要是指阿尔茨海默病(Alzheimer’s disease,AD),是常见的神经变性疾病。以往认为,AD的发病与遗传、环境因素及社会心理因素有关,其发病机制包括氧化应激、神经免疫炎症、线粒体功能障碍及胆碱能递质系统功能紊乱等。近年研究发现,血管性危险因素与认知功能损害有关,同时也参与AD的发生和发展,而高血压作为最常见的血管 Cong Yanbin ~ 1, Chi Xianglin ~ (1,2) (1. Department of Neurology, Weihai Central Hospital, Medical College of Qingdao University, Weihai, Shandong 264423; 2. Shandong University School of Medicine) Alzheimer’s disease is commonly referred to as Alz Alzheimer’s disease (AD) is a common neurodegenerative disease. In the past that the incidence of AD and genetic, environmental factors and psychosocial factors related to its pathogenesis including oxidative stress, neuroimmunity, mitochondrial dysfunction and cholinergic system disorders and so on. Recent studies have found that vascular risk factors and cognitive impairment, but also involved in the occurrence and development of AD, and hypertension as the most common blood vessels