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目的探讨肾混合性上皮间质肿瘤(MESTK)的临床病理特点、鉴别诊断和生物学行为。方法报道3例MESTK的临床、病理组织学及免疫表型并复习相关文献。结果 3例MESTK中,男性2例,女性1例;均表现为肾区肿块,无肉眼血尿,其中1例有肾区疼痛。肿块大体均呈囊实性,切面灰白、灰黄色,质韧。镜下见上皮和间质成分,上皮可围成小管状或囊腔样;间质成分为不同形态的梭形细胞,异型性不明显,核分裂象少见,可呈束状平滑肌样或卵巢样排列;其中1例PR(+)。结论肾混合性上皮间质肿瘤较少见,具有上皮和间质两种成分,是一种独立的肾肿瘤,诊断主要依靠组织病理学和免疫组化标记,由于近年来出现复发病例和恶性病例报道,其生物学行为有待进一步观察。
Objective To investigate the clinicopathological characteristics, differential diagnosis and biological behavior of mixed neoplastic epithelial tumors (MESTK). Methods The clinical, histopathological and immunophenotypes of 3 cases of MESTK were reported and relevant literature was reviewed. Results In 3 cases of MESTK, there were 2 males and 1 females; all showed masses in the kidney area without gross hematuria, of which 1 patient had pain in the kidney area. Mass generally were cystic solid, cut gray, yellowish, quality tough. Microscopic epithelial and interstitial components, the epithelium can be surrounded by a small tubular or cystic like; interstitial components of spindle cells of different forms, atypia is not obvious, mitotic figures rare, beam-like smooth muscle-like or ovary-like arrangement One case of PR (+). Conclusions Renal mixed epithelial mesenchymal tumor is rare, with both epithelial and interstitial components. It is an independent renal tumor. The diagnosis mainly depends on histopathology and immunohistochemical staining. Because of recurrence and malignant cases in recent years, Reported that its biological behavior needs further observation.