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鼻咽癌 (NPC)的化学病因主要涉及亚硝胺类化合物 ,这类物质需经体内细胞色素p450 2E1 (CYP2E1 )等酶代谢活化后方具致癌潜能。我们曾单独用二亚硝基哌嗪 (DNP)体外诱导人鼻咽上皮细胞 ,获得恶性转化表型 ,而对DNP的活化过程却不明确。方法和结果 :采用RT -P
The chemical etiology of NPC mainly involves nitrosamines. These substances need to be metabolized by the enzyme cytochrome p450 2E1 (CYP2E1) in vivo to have oncogenic potential. We have used dinitrosopiperazine (DNP) alone to induce human nasopharyngeal epithelial cells in vitro to obtain a malignant transformation phenotype, but the process of DNP activation is not clear. Methods and Results: RT-P was used