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目的观察胰岛素泵输注诺和锐短期强化治疗对初诊Ⅱ型糖尿病患者血糖、胰岛β细胞功能及CRP的影响。方法采用自身前-后对照,对83例初诊Ⅱ型糖尿病患者,应用胰岛素泵输注诺和锐进行为期2周的强化治疗,比较治疗前-后胰岛β细胞分泌指数(Homa-IS)、血清C-反应蛋白(CRP)的变化。结果患者FPG、2hPG、Homa-IR、CRP值均较治疗前显著下降(P<0.05或P<0.01),FIns、2hFIns、Homa-IS值均较治疗前显著升高(P<0.05或P<0.01)。结论胰岛素泵输注诺和锐短期强化治疗宜在T2DM患者的初诊早期应用。
Objective To observe the effect of insulin pump infusion Nuo-Rui-Rui short-term intensive therapy on blood glucose, pancreatic β-cell function and CRP in newly diagnosed type 2 diabetic patients. Methods Eighty-three patients with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in this study. Eighty-two weeks of intensified infusion of insulin pump and Novo-RUI were performed. The serum levels of Homa-IS, Changes in C-reactive protein (CRP). Results The levels of FPG, 2hPG, Homa-IR and CRP in patients were significantly lower than those before treatment (P <0.05 or P <0.01), FIns, 2hFIns and Homa-IS were significantly higher than those before treatment (P < 0.01). Conclusion The insulin pump infusion promise and sharp short-term intensive treatment should be early diagnosis of T2DM patients.