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目的探讨高敏C反应蛋白(hs-CRP)、纤溶酶原激活物抑制物-1(PAI-1)在不稳定型心绞痛(UAP)伴糖尿病(DM)患者中水平及其间的相关性。方法将149例冠心病分为3组:(UAP+DM)组40例,UAP组56例,稳定型心绞痛(SAP)组53例。分别检测入选者血清hs-CRP及血浆PAI-1的水平,分析它们在各组中的水平及它们之间的相关性。结果UAP+DM组hs-CRP水平高于UAP组[(5.2±2.7)mg/Lvs(3.8±1.9)mg/L]和SAP组[(5.2±2.7)mg/Lvs(2.0±0.9)mg/L],UAP组高于SAP组[(3.8±1.9)mg/Lvs(2.0±0.9)mg/L],差异均有统计学意义;血浆PAI-1水平UAP组高于SAP组[(1.8±0.2)A vs(0.7±0.4)A],差异有统计学意义,而(UAP+DM)组虽高于UAP组[(1.9±0.1)A vs(1.8±0.2)A],但差异无统计学意义。将149例研究对象以hs-CRP>3 mg/L为界分为两组,hs-CRP>3 mg/L组PAI-1[(1.7±0.9)Avs(1.2±0.6)A)]、空腹血糖(FPG)[(5.9±1.3)mmol/Lvs(5.1±0.7)mmol/L]及UAP发生率(40.94%vs23.48%)均高于hs-CRP≤3 mg/L组,差异均有统计学意义。相关分析显示,hs-CRP与PAI-1呈正相关,相关系数rs为0.62(P<0.01);hs-CRP与FPG呈正相关,rs为0.34(P<0.01);PAI-1与FPG呈正相关,rs为0.38(P<0.01)。结论(UAP+DM)患者体内的炎症因子hs-CRP、PAI-1水平较单纯UAP及SAP均高。
Objective To investigate the levels of hs-CRP and PAI-1 in patients with unstable angina pectoris (UAP) and diabetes mellitus (DM). Methods 149 cases of coronary heart disease were divided into three groups: 40 cases in UAP + DM group, 56 cases in UAP group and 53 cases in stable angina pectoris group. The levels of serum hs-CRP and plasma PAI-1 were determined respectively, and their levels in each group and the correlation between them were analyzed. Results The hs-CRP level in UAP + DM group was significantly higher than that in UAP group [(5.2 ± 2.7) mg / L vs (3.8 ± 1.9) mg / L] and [5.2 ± 2.7 mg / L vs 2.0 ± 0.9 mg / (P <0.01). The level of PAI-1 in UAP group was higher than that in SAP group [(3.8 ± 1.9) mg / L vs (2.0 ± 0.9) mg / L] 0.2) A vs (0.7 ± 0.4) A], but there was no significant difference between the UAP + DM group and the UAP group [(1.9 ± 0.1) A vs (1.8 ± 0.2) A] Significance of learning. The 149 subjects were divided into two groups according to hs-CRP> 3 mg / L, PAI-1 [(1.7 ± 0.9) Avs (1.2 ± 0.6) A)] with hs-CRP> 3 mg / The incidence of FPG [(5.9 ± 1.3) mmol / L vs (5.1 ± 0.7) mmol / L] and UAP incidence (40.94% vs23.48%) were higher than those with hs-CRP≤3 mg / L Statistical significance. Correlation analysis showed that there was a positive correlation between hs-CRP and PAI-1, and the correlation coefficient rs was 0.62 (P <0.01). There was a positive correlation between hs-CRP and FPG (rs 0.34, P <0.01) rs was 0.38 (P <0.01). Conclusion The levels of hs-CRP and PAI-1 in patients with UAP + DM are higher than those in UAP and SAP alone.