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53例原发性高血压患者,随机分为两组,分别用硫氮酮(diltiazem)和异搏定(verapamil)治疗,疗程4周。用双盲法观察降压效果和血脂改变。结果两组均示有明显降压效果,硫氮(艹卓)酮的降压效果又明显大于异搏定。治疗后的血脂改变,两组均显示有:HDL-C,HDL-C/TC比值,HDL_C/LDL-C比值和ApoAl的升高,且两组间比较无显著差异。这些改变均有利于防止动脉粥样硬化,故认为,两者对血脂代谢的影响虽相似,但硫氮(艹卓)酮对心脏抑制作用较异搏定为轻,降压疗效较异搏定为佳,故在治疗高血压时,硫氮(艹卓)酮更值得推广应用。
Fifty-three patients with essential hypertension were randomly divided into two groups, treated with diltiazem and verapamil respectively for 4 weeks. Double-blind observation of antihypertensive effect and blood lipid changes. Results Both groups showed significant antihypertensive effect, and the antihypertensive effect of thiamin was significantly greater than that of verapamil. There was no significant difference between the two groups in HDL-C, HDL-C / TC ratio, HDL-C / LDL-C ratio and ApoAl after treatment. These changes are conducive to preventing atherosclerosis, so that both the impact on blood lipid metabolism is similar, but the sulfur nitrogen (艹 Zhuo) ketone inhibition of cardiac arrest as compared with verapamil, antihypertensive efficacy than verapamil Better, so in the treatment of hypertension, sulfur nitrogen (艹 Zhuo) ketone more worthy of promotion and application.