一、引言肝脏是外来化学物质进行代谢、转化的主要器官,其中许多能引起肝脏明显损害,把这些化学物质称为亲肝性毒物,由此而引起的肝损伤称为中毒性肝损害。随着化学物质的种类、剂量和染毒途径不同,以及所用实验动物的种属、品系不同,肝损伤在形态学和功能上的改变也不相同,但有一些共同特点:(1)有明确的病理改变, I. INTRODUCTION The liver is the main organ for the metabolism and transformation of foreign chemicals, many of which cause significant damage to the liver. These chemicals are called hepatotropic toxicants, and the resulting liver damage is called toxic liver damage. With the different types of chemicals, different doses and exposure routes, and the different species and strains of experimental animals used, the morphological and functional changes of liver injury are also different. However, there are some common features: (1) there is a clear Pathological changes,