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蛇床子总香豆素(TCFC)5g·kg~(-1)·d~(-1)ig,每周6次,持续7wk。不脱钙骨制片测量。结果:(1)去卵巢喂水模型组胫骨骨小梁明显减少(-44％),出现骨吸收大于形成的骨高转化率。(2)用TCFC治疗的去卵巢组与(1)比胫骨骨小梁的面积增加(+41％),并降低骨高转化率的指标使基本接近对照组(除类骨质外,但矿化延迟时间不变)。本文提示TCFC可能防止绝经早期由骨高转化率引起的骨丢失。
Cnidium total coumarin (TCFC) 5g·kg~(-1)·d~(-1)ig, 6 times per week for 7 weeks. Not decalcified bone tablet measurements. Results: (1) The trabecular bone trabecular bone of the ovariectomized water feeding model group was significantly reduced (-44%), and the bone resorption was greater than the formed bone high conversion rate. (2) The area of trabecular bone in the ovariectomized group treated with TCFC was (+41%) higher than that in the tibia, and the index of reduced bone high conversion rate was basically similar to that of the control group (except osteoid, but mineral The delay time will not change). This article suggests that TCFC may prevent bone loss caused by high bone turnover in early menopause.