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SLE时患者出现B淋巴细胞的过度反应,即多克隆B细胞活化.本文说明多克隆B细胞活化的机理及病因意义,同时探讨SLE时出现免疫异常的本质.在NZB/W小鼠已证明有天然的细胞毒性自身抗体(NTA),在SLE患者末梢血中也证明有类似的扰淋巴细胞抗体.这种抗体和NTA同样对抑制性T细胞有强特异性细胞毒作用.另外,也看到SLE患者抑制性T细胞减少,其特异性表冇抗原T_5~+/T_8~+细胞减少.从功能方面研究,也看到ConA诱导
SLE patients with B lymphocyte over-reaction, that is, polyclonal B cell activation.This article describes the mechanism of polyclonal B cell activation and its etiology, and to explore the nature of immune abnormalities SLE occurred in NZB / W mice have been proven Natural cytotoxic autoantibodies (NTAs) have also demonstrated similar lymphocyte antibodies in peripheral blood of SLE patients, and this antibody and NTA have strong specific cytotoxic effects on suppressor T cells. SLE patients with suppressed T cells decreased, the specific table with antigen T_5 ~ + / T_8 ~ + cells decreased from the functional aspects of the study also saw ConA induced