阿片受体的内源性配体即内啡肽广泛分布于脑组织 胃肠道和胰岛。吗啡及β-内啡肽、脑啡肽可影响高体大鼠胰岛和灌流的狗胰腺的胰岛素分泌,但在人体脑啡肽的同类物不影响血浆胰岛素水平。作者用四个不同的化学物质(促分泌素),如葡萄糖、胆碱能激动剂氯化氨甲酰胆碱、β-肾上腺能受体激动剂间羟舒喘宁和肠促胰酶肽(CCK-8)刺激正常小鼠胰岛素分泌,整体水平观察纳洛酮的阿片受体阻断作用对基础和刺激引起胰岛素释放的影 Endorphin, the endogenous ligand of opioid receptors, is widely distributed in the gastrointestinal tract and islets of brain tissue. Morphine and beta-endorphin, enkephalin, can affect insulin secretion in the islet and perfused dog’s pancreas in high-body rats, but their congeners in the human enkephalin do not affect plasma insulin levels. The authors used four different chemicals (secretagogues), such as glucose, the cholinergic agonist carbachol, the beta-adrenoceptor agonist hydroxybutanin and the incretin peptide ( CCK-8) to stimulate insulin secretion in normal mice, the overall level of observation of naloxone opioid receptor blockade on the basis and stimulation of insulin-induced release