喜树碱(CamPtathecine)是从我国南方特有的洪桐乔木喜树(CamPtothecaacuminata Decne)的根皮、果实中提取具有抗肿瘤作用的生物碱。经药理实验与临床观察,证明对多种动物肿瘤有抑制作用,临床对消化系统肿瘤——胃癌、结肠癌、直肠癌等有较好疗效,对急性白血病、慢性粒细胞型白血病、绒毛膜上皮癌等也有一定效用。但毒性较大,有较明显的骨髓抑制、白细胞减少等,对泌尿道刺激常因尿频、血尿而中断治疗。因此依据药物的剂量来预测机体反应是不够的,按现代药理学研究,药物的作用与血药浓度有密切关系,所以建立监测病人个体血药浓度是保证安全而有效治疗的重 CamPtathecine is an alkaloid extracted from the root bark and fruit of CamPtotheca acuminata Decne, a species endemic to southern China. The pharmacological experiments and clinical observations, to prove that a variety of animal tumors have inhibitory effect on clinical digestive system tumors - gastric cancer, colon cancer, rectal cancer, etc. have a good effect on acute leukemia, chronic myelogenous leukemia, chorionic epithelium Cancer also has some useful effects. But the toxicity is greater, there is more obvious myelosuppression, leukopenia, urinary tract irritation often due to frequent urination, hematuria and interruption treatment. Therefore, based on the dose of the drug to predict the response of the body is not enough, according to modern pharmacological studies, the role of drugs and plasma concentrations are closely related, so the establishment of monitoring the patient’s individual plasma concentration is to ensure safe and effective treatment of heavy