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本文报道了纯化的αA/D干扰素(IFNαA/D)对小鼠皮下移植肉瘤的抗肿瘤作用。证明了瘤内注射效果大于全身治疗效果,并发现注射IFNαA/D后小鼠血清中α_1-酸性糖蛋白的含量显著增加。作者将甲基胆蒽诱发的小鼠成纤维肉瘤细胞(Meth-A)0.05ml(含1×10~6个细胞)皮下接种到8周龄雌性BALB/c同系小鼠体
This article reports the anti-tumor effect of purified αA/D interferon (IFNαA/D) on subcutaneously transplanted sarcoma in mice. It was proved that the effect of intratumoral injection was greater than that of systemic treatment, and it was found that the content of α 1 -acid glycoprotein in mice serum after IFNαA/D injection was significantly increased. The authors inoculated Methylcholanthrene-induced mouse fibroblast sarcoma cells (Meth-A) 0.05ml (containing 1×10~6 cells) subcutaneously into 8-week-old female BALB/c syngeneic mice.