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目的:了解抗感染药物药品不良反应(ADR)的发生特点和规律。方法:对某院2007年1月-2009年12月收集到的392例抗感染药物ADR报表进行回顾性分析。结果:女性ADR发生率(63.26%)明显高于男性(36.73%);392例ADR报表中,氟喹诺酮类(140例)和大环内酯类(133例)最多;ADR的临床表现主要为皮肤过敏反应(36.85%)和胃肠道反应(25.21%),其次是神经系统反应(12.06%);静脉给药(80.61%)是引起ADR的主要给药途径。结论:应重视抗感染药物不良反应的监测,为临床合理用药提供参考。
Objective: To understand the characteristics and rules of anti-infective drug adverse drug reaction (ADR). Methods: A retrospective analysis of 392 anti-infective drug ADRs collected in a hospital from January 2007 to December 2009 was conducted. Results: The incidence of ADR in women was significantly higher than that in men (63.26%) than in men (36.73%). Among 392 ADRs, fluoroquinolones (140 cases) and macrolides (133 cases) Skin allergic reaction (36.85%) and gastrointestinal reaction (25.21%), followed by nervous system reaction (12.06%). Intravenous administration (80.61%) was the main route leading to ADR. Conclusion: It is important to monitor the adverse reactions of anti-infective drugs and provide a reference for clinical rational drug use.