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目的探讨血管紧张素转化酶(ACE)基因I/D多态性在湖北汉族2型糖尿病发生发展中的作用。方法采用同胞对和随机病例-对照两种实验设计。征集湖北地区汉族49个同胞对及163例随机病例-对照,测定身高、体重、血压、空腹血糖等生理生化指标,应用聚合酶链反应(PCR)方法测定基因型。结果两种实验设计中对照组与病例组的基因型和基因频率均无显著差异。结论ACE基因在湖北汉族人群2型糖尿病的发生发展中可能不起主要作用。
Objective To investigate the role of angiotensin I converting enzyme (ACE) gene I / D polymorphism in the occurrence and development of type 2 diabetes in Han nationality in Hubei province. Methods Using sibling pairs and randomized case-control two experimental designs. A total of 49 sibs from Han nationality in Hubei Province and 163 randomized case-control subjects were enrolled. The physiological and biochemical indexes such as height, weight, blood pressure and fasting blood glucose were measured. The genotypes were determined by polymerase chain reaction (PCR). Results There was no significant difference in genotype and gene frequency between control group and case group in the two experimental designs. Conclusion ACE gene may not play a major role in the occurrence and development of type 2 diabetes in Hubei Han population.