目的研究左旋紫草素在不同条件下的稳定性。方法以左旋紫草素含量变化为指标,采用经典恒温法考察左旋紫草素在不同p H值磷酸缓冲溶液中的稳定性,并在此基础上考察光照、有机溶剂对其稳定性的影响。结果左旋紫草素在不同p H值稳定性不同,以p H为偏酸性较为稳定,且最适p H为3.0。结论左旋紫草素在不同条件下稳定性不同,在实际应用中应加以考虑。 Objective To study the stability of L-shikonin under different conditions. Methods The change of L-shikonin content was taken as the index. The stability of L-shikonin in different pH value phosphate buffer solutions was investigated by classical thermostat method. The effects of light and organic solvents on its stability were investigated. Results Shikonin at different pH values ​​of different stability to p H is more acidic than the more stable, and the optimum p H was 3.0. Conclusion L-shikonin has different stability under different conditions and should be considered in practical application.