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目的探讨复方肿瘤血管生成抑制因子口服液（ＣＯＬ－ＴＡＩ）与化疗药物联合对小鼠Ｓ１８０肉瘤的抑制作用。方法小鼠接种Ｓ１８０细胞后，随机分成对照组、ＣＯＬ－ＴＡＩ大剂量组、小剂量组以及各种剂量合用化疗药物实验组，１０ｄ后观察各组小鼠的肿瘤重量并计算抑瘤率。结果ＣＯＬ－ＴＡＩ不仅单独使用可抑制肿瘤生长，抑瘤率为１７．８３％～２６．９１％（Ｐ＜０．０５），而且与化疗药物合用有增强抗癌的作用，ＣＯＬ－ＴＡＩ在体内可明显增强化疗药物的抑瘤效应。单独使用环磷酰胺（ＣＴＸ）、阿霉素（ＡＤＭ）和５－氟尿嘧啶（５－Ｆｕ）时，抑瘤率分别为４１．９１％、３２．７３％和２５．９０％，三者分别与ＣＯＬ－ＴＡＩ合用时，抑瘤率分别为５７．１０％、５５．２８％和３０．２４％。结论ＣＯＬ－ＴＡＩ不仅单独使用具有抑制肿瘤生长的作用，而且与化疗药物合用有明显的增效作用。
Objective To investigate the inhibitory effects of compound tumor angiogenesis inhibitor oral liquid (COL-TAI) and chemotherapy drugs on S180 sarcoma in mice. Methods After inoculating S180 cells, mice were randomly divided into control group, high-dose COL-TAI group, low-dose group, and various doses of chemotherapeutic drugs. After 10 days, the tumor weight of each group was observed and the tumor inhibition rate was calculated. Results COL-TAI can not only inhibit the growth of tumors alone, but also inhibit tumor growth rate from 17.83% to 26.91% (P<0.05). In combination with chemotherapeutics, COL-TAI can enhance anti-cancer effects. Can significantly enhance the anti-tumor effect of chemotherapeutic drugs. When cyclophosphamide (CTX), adriamycin (ADM), and 5-fluorouracil (5-Fu) were used alone, the tumor inhibition rates were 41.91%, 32.73%, and 25.90%, respectively. When combined with COL-TAI, the tumor inhibition rates were 57.10%, 55.28%, and 30.24%, respectively. Conclusion COL-TAI can not only inhibit the growth of tumors alone, but also has a synergistic effect in combination with chemotherapeutic agents.