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目的探讨米非司酮配伍米索前列醇治疗稽留流产的临床疗效。方法选取我院2006年10月~2016年10月期间收治的200例患者为研究对象,随机将其均分为两组,治疗组(100例)给予米非司酮150mg,分次服用,2天后阴道内填塞1片米索前列醇;对照组(100例)口服已烯雌酚5mg,每日3次,连服3d,第4天静脉滴注缩宫素(5%葡萄糖液500ml+缩宫素5~10IU)。胎儿排出后24h内行B超检查,了解流产情况,观察服药效果。结果治疗组完全流产86例,占86%,不完全流产11例,占11%,无效3例,占3%,成功率为97%;对照组完全流产34例,占34%,不完全流产23例,占23%,无效43例,占43%,成功率为57%。治疗组流产成功率明显高于对照组,具有差异统计学意义(P<0.05)。结论采用米非司酮配伍米索前列醇治疗稽留流产的临床效果显著,安全可行,能有效减轻患者痛苦,该治疗方法值得推广。
Objective To investigate the clinical efficacy of mifepristone combined with misoprostol in the treatment of missed abortion. Methods A total of 200 patients admitted from October 2006 to October 2016 in our hospital were selected and randomly divided into two groups. The treatment group (100 cases) received mifepristone 150 mg twice daily Days after vaginal filling 1 misoprostol; control group (100 cases) had oral diethylstilbestrol 5mg, 3 times a day, and even served 3d, 4 days intravenous oxytocin (5% glucose 500ml + contraction Palace Prime 5 ~ 10IU). 24h after fetus discharge B ultrasound examination to understand the abortion, observation medication effect. Results In the treatment group, 86 cases were completely aborted, accounting for 86%. 11 cases were incomplete abortion, 3 cases were ineffective, 3% were ineffective, and the success rate was 97%. In the control group, 34 cases were completely aborted (34%) and incomplete abortion 23 cases, accounting for 23%, ineffective in 43 cases, accounting for 43%, the success rate was 57%. The success rate of abortion in the treatment group was significantly higher than that in the control group, with statistical significance (P <0.05). Conclusion The clinical effect of mifepristone combined with misoprostol in the treatment of missed abortion is significant, safe and feasible, and can effectively reduce the suffering of patients. The treatment is worthy of promotion.