论文部分内容阅读
目的:分析急性冠状动脉综合征(ACS)患者血N末端脑钠肽前体(NT-proBNP)水平与左心室射血分数(LVEF)的关系,并探讨维、汉民族间血浆内NT-proBNP浓度的差异及其与左室射血功能的相关性。方法:选取的对象是2012-05-2014-09在新疆医科大学与第一附属医院冠心病一科住院的维吾尔族和汉族共531例ACS患者(维族239例、汉族292例),按族别分别包括不稳定型心绞痛(UA)、急性ST段抬高型心肌梗死(STEMI)、急性非ST段抬高型心肌梗死(NSTEMI),入院后即予NT-proBNP及LVEF检测,根据LVEF值分为A组(LVEF≥50%)和B组(LVEF<50%)。结果:维吾尔族与汉族ACS患者在一般情况上差异无统计学意义(P>0.05);但两组NT-proBNP中位数有差异;差异有统计学意义(P<0.05);A组NT-proBNP(830±404)pg/ml;B组NT-proBNP(8 892±2 333)pg/ml;A组血浆NT-proBNP与LVEF无明显相关性(r=-0.13,P=0.09),B组NT-proBNP水平与LVEF呈负相关(r=-0.735,P=0.008),即随着NT-proBNP水平的升高,LVEF逐渐下降,两民族间比较有统计学差异(P<0.05)。结论:维吾尔族患者NT-proBNP水平高于相应的汉族患者。当LVEF<50%时,NT-proBNP水平与LVEF呈负相关。对于ACS患者,NT-proBNP水平亦能反映心功能状态,且与LVEF综合应用,能更好地反映患者病情,对预后有指导意义。
Objective: To analyze the relationship between the level of NT-proBNP and the left ventricular ejection fraction (LVEF) in patients with acute coronary syndrome (ACS) and to explore the relationship between NT-proBNP Concentration differences and their correlation with left ventricular ejection function. Methods: The subjects selected were 2012-05-2014-09 A total of 531 Uygur and Han patients with ACS who were hospitalized in Xinjiang Medical University and the First Affiliated Hospital of Coronary Heart Disease Section (239 Uygur and 292 Han patients) Including unstable angina pectoris (UA), acute ST-segment elevation myocardial infarction (STEMI), acute non-ST elevation myocardial infarction (NSTEMI), NT-proBNP and LVEF immediately after admission, Group A (LVEF≥50%) and Group B (LVEF <50%). Results: There was no significant difference between Uygur and Han patients in ACS (P> 0.05), but the median of NT-proBNP in both groups was significantly different (P <0.05) proBNP (830 ± 404) pg / ml; NT-proBNP (8 892 ± 2 333) pg / ml in group B; There was no significant correlation between plasma NT-proBNP and LVEF in group A (r = -0.13, The level of NT-proBNP was negatively correlated with LVEF (r = -0.735, P = 0.008). The level of NT-proBNP decreased gradually with the increase of NT-proBNP. There was a significant difference between the two ethnic groups (P <0.05). Conclusion: The NT-proBNP level in Uighur patients is higher than that in Han patients. When LVEF <50%, NT-proBNP levels were negatively correlated with LVEF. For patients with ACS, NT-proBNP levels can reflect the state of cardiac function, and combined with LVEF, can better reflect the patient’s condition, the prognosis is of guiding significance.