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目的:系统评价早期肠内营养(EEN)联合微生态制剂治疗重症急性胰腺炎(SAP)的疗效与价值。方法:计算机检索中国学术期刊全文数据库、中国生物医学文献数据库、万方医学网、维普中文期刊服务平台、Cochrane Library、PubMed、Embase、Web of Science，检索时间为建库起至2019年11月1日，采用荟萃分析方法比较在SAP患者中EEN联合微生态制剂(试验组)与仅采用EEN治疗(对照组)的临床疗效，包括血清C-反应蛋白水平、多器官功能障碍综合征发生率、胰腺感染坏死发生率、其他并发症的发生率、死亡率、住院时间等主要结局指标以及血浆白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α水平、胃肠道评分、外科干预的发生率等次要结局指标。由2名评价员严格按照纳入排除标准筛选文献、提取数据后采用Cochrane系统评价员手册5.1.0偏倚风险评估工具对纳入文献进行质量评价，采用Stata16.0软件进行荟萃分析。结果:共纳入9项临床随机对照试验研究，762例SAP患者。荟萃分析结果显示，主要结局指标中试验组与对照组患者C反应蛋白水平[均数差(n MD)＝-7.58，95%可信区间(n CI)：-23.71～8.55]、多器官功能衰竭的发生率[对数风险比(Logn RR)＝-0.30，95%n CI：-0.71～0.10]、胰腺感染坏死发生率(Logn RR＝-0.21, 95%n CI：-0.57～0.16)及死亡率(Logn RR＝0.13，95%n CI：-0.36～0.62)差异均无统计学意义(n P>0.05)。试验组并发症的发生率低于对照组(Logn RR＝-0.29, 95%n CI：-0.51～0.07)，试验组患者住院时间(n MD＝-4.45，95%n CI：-7.47～-1.43)较对照组时间短，差异具有统计学意义(n P0.05], incidence of multiple organ dysfunction syndrome [Logarithm Risk Ratio (Logn RR)=-0.30, 95%n CI: -0.71-0.10, n P>0.05], incidence of pancreatic infection and necrosis (Logn RR=-0.21, 95%n CI: -0.57-0.16, n P>0.05) and mortality rate (Logn RR=0.13, 95%n CI: -0.36-0.62, n P>0.05) the differences were not statistically significant. The incidence of complications in the experimental group was significantly lower than that in the control group (Logn RR=-0.29, 95%n CI: -0.51-0.07, n P<0.05), and the length of hospital stay in the experimental group (n MD=-4.45, 95%n CI: -7.47--1.43, n P<0.05) was significantly shorter than that in the control group. Plasma IL-8 levels (n MD=-7.43, 95%n CI: -14.28--0.57, n P<0.05), TNF-α level (n MD=-38.96, 95%n CI: -72.96--4.95, n P<0.05)and gastrointestinal score (n MD=-0.15, 95%n CI: -0.17--0.13, n P0.05) no statistical significance.n Conclusion:EEN combined with microecological preparations can reduce the length of hospital stay in SAP patients and the incidence of complications. Therefore, EEN combined with microecological agents may be beneficial for SAP patients.