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潮热是更年期综合征常见而特有的症状。大约自然绝经妇女的80%和双侧卵巢切除妇女的95%患有潮热。然而,对于潮热的发病机理至今尚未完全搞清。因此,治疗也不够理想。目前常用的雌、孕激素替代疗法对某些病人疗效欠佳,而且长期应用雌激素尚存在潜在的危险性。以往对更年期潮热发病机理的研究主要集中于由于雌激素下降而引起的中枢和外周儿茶酚胺及肾上腺素能受体的改变上。而目前内源性鸦片肽对促性腺激素释放激素(GnRH)、去甲肾上腺素和体温调节中枢的影响在更年期潮热中的作用引起了人们更大的兴趣。
Hot flashes are common and characteristic symptoms of menopausal syndrome. About 80% of naturally occurring menopausal women and 95% of women with bilateral ovariectomy have hot flashes. However, the pathogenesis of hot flashes has not yet been fully understood. Therefore, the treatment is not ideal. Currently used estrogen and progesterone replacement therapy poor efficacy in some patients, but long-term use of estrogen is still potentially dangerous. Previous studies of the pathogenesis of menopausal hot flashes have focused mainly on changes in central and peripheral catecholamines and adrenergic receptors due to decreased estrogen. At present, the effect of endogenous opioid peptides on gonadotropin-releasing hormone (GnRH), norepinephrine and thermoregulatory center in hot climactic menopause has aroused greater interest.