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目的:观察中药强骨饮对骨质疏松性股骨粗隆间骨折内固定术后患者骨代谢生化指标、骨密度及临床疗效的影响。方法:将符合本研究纳入标准的54例患者按入院顺序随机分为治疗组及对照组,治疗组27例,对照组27例。观察方法:治疗组行锁定钢板内固定术后予中药强骨饮及钙尔奇D口服治疗,对照组行锁定钢板内固定术后予口服钙尔奇D治疗,疗程为3月。术前和术后3月检测两组患者血清碱性磷酸酶(ALP)、抗酒石酸酸性磷酸酶(TRACP5b)及健侧股骨颈骨密度,并观察术后骨折愈合情况,记录患者Harris评分,所得数据进行统计分析。结果:54例入选病例有50例获得完整随访,治疗组25例,对照组25例。治疗组治疗后在骨折愈合率、骨代谢生化指标及骨密度值方面均优于对照组,差异有统计学意义(P<0.05);术后12月两组Harris评分数据比较,差异无统计学意义(P>0.05)。结论:中药强骨饮能改善骨质疏松性股骨粗隆间骨折患者骨代谢生化指标,提高骨密度,促进骨折的愈合。
OBJECTIVE: To observe the effect of Qiangguyin Decoction on biochemical markers of bone metabolism, bone mineral density and clinical efficacy in osteoporotic femoral intertrochanteric fractures. Methods: 54 patients who met the criteria of this study were randomly divided into treatment group and control group according to the order of hospitalization, 27 cases in the treatment group and 27 cases in the control group. Observations: The treatment group was treated with Qianguyin and Calcitri D after internal fixation with locking plate, and the control group received oral Calcium D treatment after locking plate fixation. The course of treatment was March. Preoperative and postoperative March, serum ALP, TRACP5b and contralateral femoral neck bone mineral density (BMD) were measured in both groups. Harris score was recorded and the Harris score was recorded. Data for statistical analysis. Results: Fifty-four patients were selected for complete follow-up, with 25 cases in the treatment group and 25 cases in the control group. After treatment, the treatment group was better than the control group in the rate of fracture healing, biochemical markers of bone metabolism and bone mineral density (P <0.05), and there was no significant difference in Harris score between the two groups Significance (P> 0.05). Conclusion: GGD can improve the biochemical indexes of bone metabolism in patients with osteoporotic femoral intertrochanteric fractures, increase bone density and promote fracture healing.