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目的:考察室温(25±1)℃下,注射用头孢替唑钠与盐酸氨溴索注射液在0.9%氯化钠注射液中的配伍稳定性。方法:采用反相高效液相色谱法-二极管阵列检测器测定头孢替唑钠与盐酸氨溴索配伍后8 h内各时间段的含量,同时测定pH,观察配伍液的外观变化。结果:8 h内配伍液外观、pH及含量均无明显变化。结论:在室温(25±1)℃8 h内,注射用头孢替唑钠与盐酸氨溴索注射液在0.9%氯化钠注射液中配伍时二者含量和pH稳定。
OBJECTIVE: To investigate the compatibility of ceftezole sodium injection and ambroxol hydrochloride injection in 0.9% sodium chloride injection at room temperature (25 ± 1) ℃. Methods: The contents of ceftezole sodium and ambroxol hydrochloride in 8 h were determined by reversed-phase high performance liquid chromatography-diode array detector. Meanwhile, the pH value was measured and the appearance of compatibility solution was observed. Results: The appearance of compatibility liquid within 8 h, pH and content showed no significant change. CONCLUSION: Both ceftezole sodium injection and ambroxol hydrochloride injection are compatible with 0.9% sodium chloride injection at room temperature (25 ± 1) ℃ for 8 h.