已知反应停能致婴儿先天性肢体缺陷(短肢或缺肢),亦有报道与保胎药、口服避孕药、盐酸吡哆醇和酒精有关。作者发现美国农业社区先天性肢体缺陷发生率升高,较正常值高2～10倍。这种状况可能与父母从事农业工作或居住在农业区有关。为确定这种关系,作者选择加利福尼亚州1982、1983、1984年的出生记录进行了病例对照研究。肢体缺陷病例237人,随机选择对照组475人,比较两组父母的职业及居住县区。调整多变量分析中的混杂因素后,估计从事农业工作父母的婴儿,其肢体缺陷的相对危 Known response can cause congenital birth defects in children (short limbs or limbs), there are also reports of tocolytic drugs, oral contraceptives, pyridoxine hydrochloride and alcohol related. The authors found that the incidence of congenital limb defects in the agricultural community in the United States increased 2 to 10 times higher than normal. This situation may be related to parents engaged in agricultural work or living in agricultural areas. To determine this relationship, the authors selected a case-control study of birth records from 1982, 1983, and 1984 in California. 237 cases of limb defects, a random selection control group of 475 people, compare the occupation of two groups of parents and living counties. After adjusting for confounding factors in multivariate analysis, it is estimated that the relative risk of limb defects in infants engaged in agricultural work