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目的探讨联合检验血清淀粉酶、脂肪酶及C反应蛋白在急性胰腺炎诊断中的价值。方法选取广元市中医院2008年3月—2011年11月收治的68例急性重症胰腺炎患者,急性轻症胰腺炎患者61例,正常对照组65例。采取酶联免疫方法测定三组患者血清淀粉酶、脂肪酶及C反应蛋白的变化水平。采取电话方式对急性胰腺炎患者进行随访,记录患者预后生活质量评分。结果重症组与其余两组对比在血清淀粉酶、脂肪酶及C反应蛋白阳性率人数上显著增高(P<0.05)。联合检查的敏感度较之单项血清淀粉酶检查有所提高,特异度有所降低(P>0.05)。结论血清淀粉酶、脂肪酶及C反应蛋白增高的患者生存质量明显下降,预后不佳,联合检测明显可以辅助提升急性胰腺炎早期的检出率,且准确性更高。
Objective To investigate the value of serum amylase, lipase and C-reactive protein in the diagnosis of acute pancreatitis. Methods Sixty-eight patients with acute severe pancreatitis admitted to Guangyuan Hospital of Traditional Chinese Medicine from March 2008 to November 2011 were selected, 61 cases were acute mild pancreatitis and 65 cases were normal control group. The levels of serum amylase, lipase and C-reactive protein in three groups were measured by enzyme-linked immunosorbent assay. Follow-up by phone to patients with acute pancreatitis, recording the prognosis of patients with quality of life score. Results Compared with the other two groups, the number of positive rate of serum amylase, lipase and C-reactive protein in severe group was significantly higher (P <0.05). The sensitivity of combined examination was higher than that of single serum amylase examination, but the specificity was lower (P> 0.05). Conclusions Patients with elevated serum amylase, lipase and C-reactive protein have a markedly decreased quality of life and poor prognosis. Combined testing can significantly improve the early detection rate of acute pancreatitis with higher accuracy.