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目的 对雌、孕激素在子宫肌瘤发病中的意义进行探讨。方法 2 4例子宫肌瘤患者 ,年龄 34～ 51岁 ,分别于手术前后测定血清中雌二醇 (E2 )、孕酮 (PRO)水平 ,计算E2 PRO比值并与 2 0例同年龄段健康体检女性进行对照。另术中取小块肌瘤及正常肌层组织制备成匀浆液测定E2、PRO。测定方法为放射免疫分析法。结果 病例组血清E2水平及E2 PRO比值明显低于对照组 ,PRO变化无意义 ;匀浆液测定肌瘤组织E2含量及E2 PRO比值高于正常肌层组织 ,有显著性差异。结论 子宫肌瘤患者血清E2 PRO比值异常是子宫肌瘤发病的重要因素 ,肌瘤局部组织内E2含量明显升高及E2 PRO比例失调可能是子宫肌瘤发病的直接原因。
Objective To investigate the significance of estrogen and progesterone in the pathogenesis of uterine fibroids. Methods Twenty-four patients with uterine fibroids aged 34-51 years were enrolled in this study. Serum estradiol (E2) and progesterone (PRO) levels were measured before and after surgery. E2 PRO ratio was calculated and compared with 20 healthy people of the same age Women to control. Another small fibroids and normal myometrial tissue preparation was homogenized to measure E2, PRO. Determination of radioimmunoassay. Results The level of serum E2 and the ratio of E2 PRO in the case group were significantly lower than those in the control group, and the change of PRO was insignificant. The content of E2 in the myoma and the ratio of E2 PRO were higher than that in the normal myometrium. Conclusion The abnormal E2 E2 ratio in patients with uterine fibroids is an important factor in the pathogenesis of uterine fibroids. The content of E2 in the local tissues of fibroids and the imbalance of E2 PRO may be the direct cause of uterine fibroids.