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目的探讨阿立哌唑治疗抽动障碍的疗效和安全性。方法将86例抽动障碍患者予阿立哌唑(5～25mg/d)治疗,共治疗8周。采用耶鲁抽动严重程度总体量表(YGTSS)、副反应量表(TESS)于治疗前、治疗第2、4、8周末对患者进行评估。结果患者第2、4、8周末严重程度得分与治疗前相比均有明显下降,差异有极显著性(P<0.01)。患者在治疗2、4周末副反应与治疗前相比差异有显著性(P<0.05),而第8周末与治疗前相比差异无显著性(P>0.05)。结论阿立哌唑能有效改善运动及发声抽动,副作用较轻。
Objective To investigate the efficacy and safety of aripiprazole in the treatment of tic disorder. Methods Totally 86 patients with tic disorder were treated with aripiprazole (5 ~ 25mg / d) for 8 weeks. Patients were assessed using the Yale Scale for Tight Severity Scale (YGTSS) and the TESS (Side Effects Scale) before treatment and at the end of Weeks 2, 4 and 8. Results At the end of 2, 4, and 8 weeks, the scores of severity of patients decreased significantly compared with that before treatment, the difference was significant (P <0.01). There was a significant difference (P <0.05) in side effects between the two groups at the end of 2 and 4 weeks, but no significant difference at the end of 8th week (P> 0.05). Conclusion Aripiprazole can effectively improve the movement and vocal twitch with less side effects.