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目的:观察自拟方剂与小剂量西药联用预防小儿支气管哮喘发作的临床疗效。方法:选择该院自2010年1月～2011年10月收治的140例小儿支气管哮喘患儿,按照患儿家长自愿原则,随机分为实验组与对照组。实验组70例,口服哮喘清合剂加用小剂量西药;对照组70例,吸入糖皮质激素和(或)孟鲁斯特钠咀嚼片,观察3个月为1个疗程。同时在发作期、缓解期及1个疗程结束后分别做嗜酸粒细胞计数、FENO、肺功能水平。结果:治疗组的总有效率为91.43%(64/70),高于对照组总有效率70.00%(49/70),具有统计学意义(P<0.05);治疗组在肺功能、嗜酸粒细胞计数、FENO指标比较,有统计学差异(P<0.05)。结论:中西医结合疗法防治小儿支气管哮喘,其疗效显著,能明显改善患者的临床症状,提高治愈率,同时安全性高,值得进一步推广应用。
Objective: To observe the clinical efficacy of self-made prescription and small dose of western medicine in preventing bronchial asthma attack in children. Methods: A total of 140 children with bronchial asthma who were admitted to our hospital from January 2010 to October 2011 were randomly divided into experimental group and control group according to the voluntary principle of children. Experimental group of 70 cases, oral asthma mixture plus a small dose of western medicine; control group of 70 cases, inhaled corticosteroids and (or) montelukast sodium chewable tablets, observed 3 months as a course of treatment. At the same time in the attack, remission and after a course of treatment were done eosinophil count, FENO, pulmonary function. Results: The total effective rate of the treatment group was 91.43% (64/70), higher than that of the control group (70.00%, 49/70), with statistical significance (P <0.05) Granulocyte count, FENO index was statistically significant (P <0.05). Conclusion: Integrative medicine prevention and treatment of bronchial asthma in children, its curative effect is obvious, can significantly improve the clinical symptoms of patients and improve the cure rate, while high safety, it is worth further promotion and application.