死于青霉素过敏的首例报道是在该药被引进一年之内的1948年.此后人们对青霉素及其合成类似物的“过敏反应”已逐步有所认识,但真正的IgE依赖性过敏是罕见的.在所有接受青霉素治疗的病人中,过敏反应发生率约为0.05％,死亡率为0.0002％左右.多数过敏反应发生在胃肠外给药后,这似乎与特应性无关.其他对青霉素过敏反应的病人(发病率占病人 The first reported death from penicillin allergy was introduced in a year after the drug was introduced in 1948. Since then there has been a growing awareness of the “allergic reaction” of penicillins and their synthetic analogs, but true IgE-dependent allergy is Rare .Among all penicillin-treated patients, the incidence of anaphylaxis is about 0.05% and the mortality rate is about 0.0002% .Most of the allergic reactions occur after parenteral administration, which seems to be independent of atopy. Penicillin allergic reaction patients (incidence rate of patients