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血液中的甲状腺激素T_4,绝大部份是以与甲状腺素结合蛋白(TBP)相结合的形式存在的。不与蛋白结合的游离甲状腺素FT_4,不超过总T_4的0.02～0.04%。真正在靶器官起生理作用的就是这极少部份具有生物活性的FT_4。血液中的总T_4量受TBP的影响。但FT_4不受它的影响,甲状腺的机能状态取决于血循环中FT_4的水平,由于FT_4不受TBP浓度变化的影响,从理论上讲,可以认为测定FT_4的水平,才能最准确地反映甲状腺的功能状态。临床上常规应用血清总T_4含量及~(125)Ⅰ-T_3摄取比值的测定来检查甲状腺功能。由于血清
The blood thyroid hormone T_4, the vast majority is with the thyroxine binding protein (TBP) in the form of binding. The free thyroxine FT_4 that is not bound to the protein does not exceed 0.02 to 0.04% of the total T_4. Really play a role in the target organ is this very few biologically active FT_4. The total amount of T_4 in the blood is affected by TBP. However, FT_4 is not affected by it. The thyroid function depends on the level of FT_4 in the blood circulation. Since FT_4 is not affected by changes in TBP concentration, it is theoretically possible to determine the level of FT_4 to reflect the thyroid function most accurately status. Thyroid function was examined routinely using routine serum T 4 levels and ~ (125) I-T 3 uptake. Because of serum