裸小鼠,是六十年代初发现的一种自发无毛突变种。Flanagan(1966)第一次详细描述其产生,遗传学背景和一般特征。1968年Pantelouris证实两性及任何年龄的裸小鼠出生时缺乏胸腺,故称之为“先天性无胸腺小鼠”(Athymic mice)。由于裸小鼠胸腺缺乏,细胞免疫缺陷,故可接受同种 Naked mice, a spontaneous hairless mutant found in the early 1960s. For the first time Flanagan (1966) described its production, genetic background and general characteristics. In 1968 Pantelouris confirmed that both sexes and nude mice of any age lacked the thymus at birth and were called “Athymic mice.” Due to the lack of thymus in nude mice, cell immunodeficiency, they can accept the same species