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前曾报道β-(5-硝基-2-呋喃)丙烯酰胺类衍生物(Ⅰ)有显著的抗口本血吸虫作用,其中尤以F-30066(B=NHC_3H_7-iso)及F-30069(B=NHCH_2COOC_2H_5)杀虫效力最强,前者已用于临床。
It was previously reported that β-5-nitro-2-furan (acrylamide) derivatives (Ⅰ) have significant anti-Schistosoma japonicum effect, especially F-30066 (B = NHC_3H_7-iso) and F-30069 B = NHCH_2COOC_2H_5) insecticidal effect of the strongest, the former has been used in clinical.