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目的观察氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停的疗效。方法 60例原发性呼吸暂停早产儿随机分为两组,在常规治疗基础上,两组均应用氨茶碱,首剂5 mg/kg,12 h后给予维持量2.5 mg/kg,每12 h给药1次;治疗组加用纳洛酮10μg/(kg.h),每8 h或12 h给药1次。结果治疗组总有效率为93.3%,对照组总有效率为70.0%。两组总有效率比较差异有统计学意义(χ2=4.01,P﹤0.05)。结论氨茶碱与纳洛酮联合应用优于单纯用氨茶碱治疗早产儿原发性呼吸暂停。
Objective To observe the efficacy of aminophylline combined with naloxone in the treatment of premature infants with primary apnea. Methods Sixty preterm infants with primary apnea were randomly divided into two groups. On the basis of routine treatment, aminophylline was given in both groups with the first dose of 5 mg / kg and the maintenance dose of 2.5 mg / kg after 12 h, with 12 h once a day; the treatment group plus naloxone 10μg / (kg.h), administered every 8 h or 12 h. Results The total effective rate was 93.3% in the treatment group and 70.0% in the control group. The total effective rate between the two groups was statistically significant (χ2 = 4.01, P <0.05). Conclusion The combination of aminophylline and naloxone is superior to the simple use of aminophylline in the treatment of premature infants with primary apnea.