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目的 :研究高效抗逆转录病毒治疗 (HAART)后 T细胞亚群上第二受体的变化及其意义。方法 :采用流式细胞仪检测 CD4 + 、CD8+ 、CD4 + CD4 5 RA+ 以及 CD4 + CD4 5 RO+ 细胞表面 CCR5及 CXCR4的表达水平。结果 :HIV感染后 ,第二受体在 CD4和 CD8以及记忆型和处女型 CD4 T细胞亚群上的表达水平 ,与正常对照没有显著性差异。 HAART治疗仅能在一定程度上改变细胞表面的第二受体水平。结论 :第二受体参与了 HIV的致病过程 ,B期之前开始抗病毒治疗将有较好的疗效。
Objective: To investigate the significance of the second receptor on T lymphocyte subsets after HAART. Methods: The expression of CCR5 and CXCR4 on CD4 +, CD8 +, CD4 + CD4 + RA + and CD4 + CD4 + RO + cells were detected by flow cytometry. RESULTS: After HIV infection, the level of expression of the second receptor on CD4 and CD8 as well as on memory and viroid CD4 T-cell subsets was not significantly different from the normal controls. HAART treatment can only alter the level of the second receptor on the cell surface to some extent. Conclusion: The second receptor is involved in the pathogenesis of HIV, and antiviral therapy before Phase B will have a good effect.